Strategies for specific immunomodulation in transplantation

Strategies for Antigen-Specific Immunomodulation in Experimental Organ Transplantation

Statin Immunomodulation: Role in Transplantation and Disease Conditions

The pleiotropic effects of statins suggest that their therapeutic benefits may probably extend beyond cholesterol lowering in cardiovascular disease to organ transplantation and other disease conditions, particularly autoimmune disease. This is attributable to their modulating influence on immune mechanisms mediated by inhibition of prenylated proteins. Isoprenoid intermediates generated by the...

Subunit specific inhibitors of proteasomes and their potential for immunomodulation.

Specialized variants of the constitutive 20S proteasome in the immune system like the immunoproteasomes and the thymoproteasome contain active site-bearing subunits which differ in their cleavage priorities and substrate binding pockets. The immunoproteasome plays a crucial role in antigen processing and for the differentiation of pro-inflammatory T helper cells which are involved in the pathog...

Lymphodepletional strategies in transplantation.

Because lymphocytes were shown to mediate transplant rejection, their depletion has been studied as a mechanism of preventing rejection and perhaps inducing immunologic tolerance. Agents that profoundly deplete lymphocytes have included monoclonal antibodies, cytotoxic drugs, and radiation. We have studied several such agents but focused on antibodies that deplete not only peripheral blood lymp...

Neuroprotection in the Injured Spinal Cord Novel Strategies using Immunomodulation, Stem cell Transplantation and Hyaluronic acid Hydrogel carriers

Schizas, N. 2015. Neuroprotection in the Injured Spinal Cord. Novel Strategies using Immunomodulation, Stem cell Transplantation and Hyaluronic acid Hydrogel carriers. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1106. 59 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9255-7. The overall aim of this thesis was to establish strategies to min...